Forensic Genomics

LEANGENE provides solutions for Forensic Laboratories using Illumina next-generation sequencing (NGS) technology. 

Illumina NGS technology and informatics deliver far more insight from forensic DNA than traditional methods, with a much higher resolution than ever before possible. More efficient answers with a greater degree of certainty.

NGS allows examiners to generate data that span the human genome and address a wider range of questions in a single, targeted assay. Moreover, NGS-generated STR allele calls are fully compatible with current database formats. Early studies provide a promising view of the advantages NGS brings to analysis of even the smallest, most compromised, and highly mixed evidentiary samples.

  NGS enables genetic analysis for large numbers of globally relevant STR markers and dense SNP sets in a single test.

  NGS can help labs produce high-quality forensic profiles for national DNA databases, with a faster turnaround.

With the power of NGS, you can extract maximum information from limited samples, get accurate, actionable clues that can help you find missing persons and solve criminal cases.

 

Solutions for Criminal Casework

7j1xdd7The Illumina forensic genomics solution generates the maximum information possible from criminal casework samples. Next-generation sequencing (NGS) allows crime laboratories to simultaneously analyze every locus currently in use, plus hundreds more, from less than 1 nanogram of sample.

In forensic genomics laboratories worldwide, challenging DNA samples are sometimes interrogated multiple times in an attempt to extract a full set of data. This testing might include autosomal short tandem repeat (STR) analysis, mitochondrial DNA (mtDNA) sequencing, Y-STRs, and single nucleotide polymorphisms (SNPs).

Disaster Victim Identification

forensics disaster victim identification web graphicGenetic analysis can help identify victims of mass fatalities when traditional methods cannot be used, or fail to yield conclusive results. Because next-generation sequencing (NGS) has no relevant limit on the number of loci that can be simultaneously analyzed, you can extract the maximum amount of information from evidence or a known reference sample.

Conventional disaster victim identification methods include fingerprints and odontology. Labs also use molecular methods such as DNA analysis and mitochondrial DNA (mtDNA) sequencing with capillary electrophoresis. Sample types processed after a mass fatality event can include bone fragments, tissue, various personal effects containing DNA, and buccal swabs from relatives.

LeanGene provides solutions for Forensic Laboratories using Illumina next-generation sequencing (NGS) technology.

 

Illumina NGS technology and informatics deliver far more insight from forensic DNA than traditional methods, with a much higher resolution than ever before possible. More efficient answers with a greater degree of certainty.

NGS allows examiners to generate data that span the human genome and address a wider range of questions in a single, targeted assay. Moreover, NGS-generated STR allele calls are fully compatible with current database formats. Early studies provide a promising view of the advantages NGS brings to analysis of even the smallest, most compromised, and highly mixed evidentiary samples.

  NGS enables genetic analysis for large numbers of globally relevant STR markers and dense SNP sets in a single test.

  NGS can help labs produce high-quality forensic profiles for national DNA databases, with a faster turnaround.

With the power of NGS, you can extract maximum information from limited samples, get accurate, actionable clues that can help you find missing persons and solve criminal cases.

  Get an introduction to NGS and its uses in forensic genomics.

Identification of Missing Persons

forensic printIllumina sequencing by synthesis (SBS) technology offers a massively parallel approach for sequencing forensic PCR amplicons, both nuclear and mitochondrial. NGS enables scientists to utilize a single platform and optimal workflow to overcome the widest range of difficult samples often encountered in missing persons cases.

Illumina forensic genomics solution includes a dense set of identity SNPs, phenotypic SNPs, and biogeographic ancestry SNPs to assist in facial reconstruction and to eliminate candidate identifications.

Forensic DNA Database

Next-generation sequencing (NGS) offers an opportunity for efficient DNA database sample turnaround. DNA profiling with NGS enables law enforcement investigations to more quickly identify suspects and links between forensic cases.

Millions of DNA profiles are curated in national and international DNA databases. These profiles assist law enforcement agencies in identifying perpetrators, linking multiple crime scenes, and resolving missing persons cases.

NGS gives labs more options for producing high-quality forensic DNA profiles.

MiSeq FGx Forensic Genomics System

system banner miseq fgxThe MiSeq FGx Forensic Genomics System is the first fully validated, next-generation sequencing (NGS) solution designed for forensic science. Dedicated library kits and analytical software take you from DNA-to-answer with streamlined efficiency.

Top10Logo OptimizedThe MiSeq FGx Forensic Genomics System won the #2 spot on The Scientistā€™s List of Top 10 Innovations for 2015.

 

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