There are autoimmune conditions with a strong association with HLAs, such as: Ankylosing Spondylitis, Narcolepsy, Coeliac Disease and Drug hypersensitivity - Abacavir. Olerup SSP® kits for the screening of disease associated HLA-alleles includes master mixes containing cresol red, glycerol, PCR buffer and dNTPs with or without Taq polymerase.
Disease Associated Alleles
Ankylosing Spondylitis
Ankylosing Spondylitis (AS) is a type of arthritis in which there is long term inflammation of the joints of the spine. It mainly affects patients' back.
Ankylosing Spondylitis is associated to HLA-B*27. We offer SSP kits for the screening of B*27 associated with AS and kits for high resolution of HLA-B*27.
Coeliac Disease
Coeliac Disease also know as celiac disesase mainly affects the small intestine. It is a lifelong autoimmune condition where the body’s immune system reacts to gluten, a protein found in wheat, and other grains. The body’s reaction to gluten causes damage to the lining of the intestine and can lead to malnutrition.
Over 95% of patients with Coeliac Disease have some isoform of HLA-DQ2 or DQ8. We offer SSP kits for typing of DQB1 and DQA1 alleles associated with Coeliac Disease (DQA1*02,05;DQB1*02,03:02)
Narcolepsy
Narcolepsy is a long term neurological disorder that involves a decreased ability to regulate sleep-wake cycles.
Narcolepsy is a neurological disease closely associated with the HLA-DQB1*06:02. We offer SSP kits for typing of DQB1 and DQA1 alleles associated with Narcolepsy (DQB1*06:02,DQA1*01:02).
Abacavir
Abacavir is a nucleoside reverse transcriptase inhibitor used in conjunction with other antiretroviral agents in the treatment of HIV infection. Hypersensitivity to abacavir is immunologically mediated, driven by conventional MHC-I antigen presentation and activation of HLA-B*57:01.
Abacavir HSR (Hyper Sensitivity Reaction) has been strongly associated with HLA-B*5701. We offer SSP kits for typing of B*57:01, associated with HSR to Abacavir.
