The inventor and manufacturer of MLPA!
MRC Holland b.v. is a biotechnology company located in Amsterdam, the Netherlands. The company is a follow-up of Microbiology Research Centre Holland, founded in 1985 by Dr. Jan Schouten. Until 2000, the main products of MRC Holland were restriction endonucleases—purified from a wide range of bacteria and blue green algae—and DNA molecular weight markers. These products were sold in bulk amounts to distributing companies worldwide.
In 1997, MRC Holland started focusing on developing new techniques for DNA analysis. By far the most successful technique developed is Multiplex Ligation-dependent Probe Amplification, or MLPA®. The MLPA® technology was first described in Nucleic Acids Research 30, e57 (2002) by Schouten et al. Since then, hundreds of MLPA probe sets have been developed for a wide variety of genes and applications, some of which very rare.
At present, all activities of MRC Holland are directed to the production of new MLPA-based products and the development of novel MLPA-based techniques. MRC Holland currently has more than 80 employees, working in development, quality testing, production, sales and customer service.
As the inventor and manufacturer of MLPA, MRC Holland offers 400 different MLPA panels. Popular applications include Predisposition to Cancer, Neuromuscular Disorders, Intellectual Disability & Solid Tumours.
